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Ingredients: 10mg Epithalamin Proteins
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Epitalon is a synthetic peptide, telomerase activator, and putative anti-aging medication produced by the St. Petersburg Institute of Bioregulation and Gerontology, that was recognized as the putative active element of a bovine pineal gland infusion called epithalamin.
Epitalon and epithalamin seem to revive melatonin secretion from the pineal gland in both elderly monkeys and people.
Epitalon seems to inhibit the synthesis of this MMP9 protein at vitro in aging skin fibroblasts.
Epitalon is a tetrapeptide using all the amino acid sequence Ala-Glu-Asp-Gly as well as the molecular formula C14H22N4O9.
Epitalon reduced the amount of spontaneous tumors along with the amount of metastases in mice that did develop spontaneous tumors in an experiment on one-year-old female C3H/He mice, and is supposed to have oncostatic and anti-metastatic properties.
Another research in aging rats discovered that epitalon improved the actions of these antioxidant enzymes superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase.
Another research in aging rats revealed extension of life span for rats exposed to continuous illumination or into a natural mild regimen average of northern areas.
An individual clinical trial conducted on a sample of retinitis pigmentosa patients discovered that epitalon generated a positive clinical impact in 90 percent of cases in the treated group.
Elongation of telomeres from epitalon was enough to transcend the Hayflick limit at a cell culture of human fetal fibroblast cells, extending their proliferative possible from conclusion in the 34th passing from the control cell population to outside the 44th passing at the treated cell population, while raising the lengths of the telomeres to levels similar to those of cells at the first culture.
The Epitalon peptide seems to induce telomere elongation via enhanced telomerase action in human somatic cells at vitro, according to a research in human fibroblast mobile cultures.
Epitalon induces decondensation of heterochromatin close to the centromeres in cultured lymphocytes originating from samples obtained from people of ages 76 to 80 decades.
An in vivo research in aging mice discovered that epitalon treatment considerably reduced the prevalence of chromosomal aberrations, both for wild-type mice and also for mice characterized by an accelerated aging phenotype, which is consistent with gains in telomere length.
In clinical trials, lengths increased in the blood cells of individuals of 75-80 and ages 60-65, and their effectiveness has been like one another.
Another potential cohort study on a sample of 79 coronary patients spanning in excess of 12 years discovered enhanced metrics of bodily endurance, circadian rhythm, and carbohydrate and lipid metabolism from the treated group relative to the control group after 3 decades of biannual epithalamin remedies, in addition to a 50% lower rate of cardiovascular mortality, and a 50 percent reduced rate of cardiovascular collapse and severe respiratory disorder , along with a 28% reduced rate of total mortality.
Individual clinical studies
An individual prospective cohort study conducted on a sample of 266 individuals over age 60 revealed that therapy with epithalamin, the pineal hormone infusion upon which epitalon relies, generated a 1.6–1.8-fold decrease in mortality through the subsequent 6 decades, a 2.5-fold decrease in mortality when coupled with thymulin, along with a 4.1-fold decrease in mortality when coupled with thymulin and administered yearly rather than just once at study onset.
Epitalon seems to improve the proliferation of lymphocytes from the thymus, putatively raising generation of interferon gamma by T-cells.
Research from vitro
In a study of hens exposed to neonatal hypophysectomy and following maturation, epitalon encouraged the recovery of their morphological structures of their thymus, in addition to the arrangement and use of this thyroid gland.
Most research on epitalon and epithalamin have been conducted from the St. Petersburg Institute of Bioregulation and Gerontology, chiefly modulated by Vladimir Khavinson, in Russia.
In a different human clinical trial conducted on a sample of pulmonary tuberculosis sufferers, epitalon did not seem to fix preexisting structural aberrations of chromosomes related to telomere degradation, but didn’t seem to exert a protective influence against the future development of additional chromosomal aberrations.